Plants in the mainly tropical and subtropical Milkweed Family (Asclepiadaceae) are annual and perennial herbs, shrubs, and vines with milky sap, simple, usually opposite or whorled leaves, flowers with 5 petal-like, often reflexed sepals, 5 fused stamens that form a central filament column, and 2 superior ovaries, and fruit in the form of dry seed pods filled with numerous seeds. The seeds have tufts of silky hair.

Listed below are some of the southeastern Arizona plants in this family.

Note: Although not every source currently lists it as such, this family may now be treated as a subfamily (Asclepiadoideae) of the Dogbane Family (Apocynaceae).