Plants in the mainly tropical Cucumber Family (Cucurbitaceae) are annual and perennial herbs, vines, and lianas with simple, alternate, often palmately lobed leaves, twining tendrils, flowers with 5 lobes, 5 sepals, and an inferior ovary, and fleshy or capsular, usually melon-like or gourd-like fruit.

Listed below are some of the southeastern Arizona plants in this family.