Plants in the mainly western U.S. Waterleaf Family (Hydrophyllaceae) are usually hairy, annual and perennial herbs, subshrubs, and shrubs with opposite, alternate, or basal, simple or pinnately compound leaves, bisexual, bell-shaped or funnel-shaped flowers with generally 5 lobes, 5 united sepals, and a superior ovary, and fruit in the form of a multi-seeded capsule.

Listed below are some of the southeastern Arizona plants in this family.