Plants in the especially tropical and subtropical Milkwort Family (Polygalaceae) are annual and perennial herbs, shrubs, trees, and vines with simple, alternate, opposite, or whorled leaves, bisexual flowers with 3 or 5 petals, 5 sepals, and a superior ovary, and fruit in the form of a capsule, nut, or fleshy drupe.

Listed below are some of the southeastern Arizona plants in this family.